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News

Welcome Anya!
We are excited to welcome new PMI student Anya Ranaraja to the lab. She will work on projects related to ILC2 plasticity and Blimp-1. We are excited for all she will achieve in her PhD!

Our first study on Blimp-1 and ILC2s was published in Nature Immunology 

IL-9 and Blimp-1 protect the transcriptional identity of group 2 innate lymphocytes in allergic asthma

Congrats to Yibo and all authors on this exciting new function of Blimp-1!

Amanda is promoted to Associate Professor!

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9/22/2025

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Poholek Lab at the 2025 Pitt Immunology Retreat

9/25/2025

Talks by Aaron, Harshita and Amanda and posters by Harshita Yijia and Xingjian

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Farewell to our summer high school student Catherine Yang. Thanks for all your help this summer!

8/25/2025

7/7/2025

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Yibo's Farewell BBQ

Best of luck to Yibo (and Xu from the Hand lab) on your next steps in finishing your medical training at Tsinghua. Thank you for all your hardwork and dedication in the last 4 years! We will miss you greatly!

Check out this great summary from UPMC about our recent paper on the regulation of T cells in allergic asthma 

2 Papers out this week from the Poholek Lab

Oct 11, 2024

The Nature Immunology paper was spearheaded by our previous post-doc, Dr. Kun He, which investigates the molecular mechanisms of Th2 to drive allergic asthma. Using complex mouse models to investigate the role of Blimp-1 and spatial transcriptomics, they identify a key role of Il-2 and IL-10 to drive disease.

The npj systems biology and applications paper is a review paper written by PMI student Aaron Yang who discusses key sequencing methods to investigate the transcriptomic and epigenetic landscapes of T cell regulation in disease. 

Congrats to Aaron for winning 1st place poster award at the Pitt annual immunology retreat

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9/27/2024

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Congrats to Kun and team for his manuscript accetance to Nature Immunology! Celebrating with the lab/collaborators at Puttery with Yibo taking the victory.

9/14/2024

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We moved to Assembly

Big change for the lab as we move from Rangos to Assembly! (9/1/24)

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Congratulations to post-doc Kun He for winning 1st place poster award at the annual Pitt Immunology retreat

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And 4th year PMI student Aaron Yang won 2nd place poster award

Sept 2023

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Penn State Chromatin Meeting

Aaron and Amanda Attend the Penn State Chromatin Symposium to expand our research program on chromatin and epigenetics.

Rhodes' Thesis Defense Celebration!

"Tumor microenvironmental signals reshape chromatin landscapes to limit the functional potential of exhausted T cells"​

We are very excited for our recent publication in Science Immunology with our collaborators at the Delgoffe lab to use CUT&RUN to epigenetically profile T cells as they progress to exhaustion in cancer. Read the paper below! (8/5/22)

Aaron adn Rhodes attend FASEB in Nova Scotia

Rhodes and Aaron attend FASEB Meeing in Nova Scotia

Congrats to our summer undergraduate students for successful summer projects and learning!

Amanda Crocker's end of summer talk

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Nicole Gurvich end of summer research poster (7/29/22)

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Going away party at Walters for our undergraduate student Abby Berrios. Congratulations on graduating from Pitt and your next role at Abound Bio. (4/2022)

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Welcome to our new Tsinghua Scholar, Yibo Zheng! We are excited to have you in the lab! (1/2022)

Congrats to 4th year PMI student Rhodes Ford on winning the 1st place poster award at the 2021 University of Pittsburgh Immunology Retreat (October 2021)

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Welcome to our new research Technician Jiaqi "Jack" Lu to the lab. (October 2021)

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