Key Publications

Submitted and Published Papers

Publications: Publications

Tumor microenvironmental signals reshape chromatin landscapes to limit the functional potential of exhausted T cells

August 5, 2022; Science Immunology

B. Rhodes Ford*, Paolo D.A. Vignali*, Natalie L. Rittenhouse*, Nicole E. Scharping*, Ronal Peralta, Konstatinos Lontos, Andrew T. Frisch, Greg M. Delgoffe*, Amanda C. Poholek*

Link to paper

Tissue-Specific Contributions to Control of T Cell Immunity

June 8, 2021; ImmunoHorizons

Amanda C. Poholek

Blimp-1 is Essential for Allergen-induced Asthma and Th2 Cell Development in the Lung

May 12, 2020; Journal of Experimental Medicine

Kun He*, Angela Hettinga*, Sagar L. Kale, Sanmei Hu, Markus M. Xie, Alexander L. Dent, Anuradha Ray, Amanda C. Poholek

Pubmed

Additional Publications:

Scharping NE, Rivadeneira DB, Menk AV, Vignali PDA, Ford BR, Rittenhouse NL, Peralta R, Wang Y, Wang Y, DePeaux K, Poholek AC, Delgoffe GM. Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion. Nat Immunol. 2021 Feb;22(2):205-215. doi: 10.1038/s41590-020-00834-9. Epub 2021 Jan 4.

Poholek AC, Jankovic D, Villarino AV, Petermann F, Hettinga A, Shouval DS, Snapper SB, Kaech SM, Brooks SR, Vahedi G, Sher A, Kanno Y, O'Shea JJ. IL-10 induces a STAT3-dependent autoregulatory loop in TH2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes. Sci Immunol. 2016 Oct;1(5):eaaf8612. doi: 10.1126/sciimmunol.aaf8612. Epub 2016 Nov 11.

Poholek AC, Hansen K, Hernandez SG, Eto D, Chandele A, Weinstein JS, Dong X, Odegard JM, Kaech SM, Dent AL, Crotty S, Craft J. In vivo regulation of Bcl6 and T follicular helper cell development. J Immunol. 2010 Jul 1;185(1):313-26. doi: 10.4049/jimmunol.0904023. Epub 2010 Jun 2. PMID: 20519643; PMCID: PMC2891136.

Johnston RJ, Poholek AC, DiToro D, Yusuf I, Eto D, Barnett B, Dent AL, Craft J, Crotty S. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science. 2009 Aug 21;325(5943):1006-10. doi: 10.1126/science.1175870. Epub 2009 Jul 16. PMID: 19608860; PMCID: PMC2766560.

Vahedi G, C Poholek A, Hand TW, Laurence A, Kanno Y, O'Shea JJ, Hirahara K. Helper T-cell identity and evolution of differential transcriptomes and epigenomes. Immunol Rev. 2013 Mar;252(1):24-40. doi: 10.1111/imr.12037. PMID: 23405893; PMCID: PMC3577092.

Publications: Text