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Research Areas
Functional spatial niches promote T cell outcomes
Using spatial transcriptomics, computational approaches and genetic perturbation, we aim to identify, characterize and determine the functional importance of microniches in lymph nodes and the lung that promote inflammation in allergic asthma.
Transcription factor control of cellular state
Using Blimp-1 as a model TF, we are exploring the regulation of Blimp-1 across immune cell types and the cell-specific functions in diseases such as allergic asthma and cancer.
Epigenetic regulation of T cell functional states
Chromatin modifiers and non-coding DNA elements control cell-type specific genes in a context-dependent manner. We aim to discover and characterize epigenetic regulators that control the transcriptional state in settings such as CD8 T cell exhaustion.
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